Physiology 2021

Thank you to everyone that joined us from across the world – close to 600 people connected with our conference platform to come together to celebrate first-class physiology!

Our Annual Conference, Physiology 2021, was attended by a vibrant community of scientists from 45 countries. Across five days, Physiology 2021 featured 95 ePosters, 83 Oral Communications, 72 Symposia speakers and 7 Prize Lectures.

Following the conference, Dariel Burdass, Chief Executive, said:

“The Physiological Society’s Annual Conference always brings together an exceptional scientific and professional development program and this year was no exception. During the five days, hundreds of physiologists from across the world came together in a true celebration of our discipline. We couldn’t do this without the enthusiasm of all our members and the wider physiology community, and I would like to thank them for bringing such energy combined with high quality science to the week. It was also great to see the innovative networking features of the platform being used so well, with so many members forging new connections with their peers. I would also like to take this opportunity to thank our Conference Committee and the staff at The Society for all their hard work.“

Dr Sue Deuchars, Chair of our Conferences Committee, summed up the conference perfectly in her closing remarks, when she said:

“It has given everyone at all levels a chance to present and to share their fantastic research, from undergraduates right up to professors and, despite the pandemic, there has been some fabulous research happening across the physiology community. We’ve had posters on all subjects and the presenters have provided some great video presentations.”

Professor David Paterson, President of The Physiological Society, closed the conference by saying:

“Whilst it would be great to be able to meet in person, technological platforms also have their opportunities – we have had people join from 45 different countries, which has given us a really international perspective. Having said that, we hope that we will see you all next year, particularly in Copenhagen at Europhysiology 2022!”

Stay up to date with our future events, check out our events listing.

Teaching physiology: Past, present, and future

Dr James Clark, King’s College London, UK

Cardiac Sodium Channel: From Function to Dysfunction

Organised by Dr Andrew James, University of Bristol, UK and Dr Kamalan Jeevaratnam, University of Surrey, UK

For publication in The Journal of Physiology.

Activation of the voltage-gated sodium channel underlies the upstroke of the cardiac action potential, its subsequent inactivation being fundamental to the establishment of a refractory period. Thus, the sodium channel is central to the orderly conduction of electrical activity through the heart and represents an important target for antiarrhythmic drugs. Biophysical and structural studies on mutations of the cardiac sodium channel known to cause arrhythmia and hypertrophic cardiomyopathy have provided insight both into the structural basis of channel function and into the physiological role of the channel. A picture is emerging of sodium channels existing in distinct subdomains at the surface sarcolemma and at the intercalated disks, differentially regulated according to the ancillary proteins and beta-subunits. This symposium aims to provide a contemporary overview of the structure and function of the cardiac sodium channel, the clinical and biophysical characteristics of its dysfunction, and the pharmacological options for the treatment of the associated disorders. Particular focus is placed on the late component of the Na⁺ current, which arises from the incomplete inactivation of sodium channels and is increased in a number of acquired and congenital conditions, influencing the shape and duration of the action potential and Ca²⁺ homeostasis with consequences on arrhythmia susceptibility and development of cardiomyopathy.

Supported by Nanion Technologies GmbH

Changes in cellular Ca2+ and Na+ regulation during the progression towards heart failure: Professor Ken Macleod, Imperial College London, UK
Cardiac sodium channel (dys)function and arrhythmias: Novel mechanisms and therapeutic targets: Professor Carol Ann Remme, Academic Medical Center Amsterdam, The Netherlands
Structural and functional roles of the β3-subunit on the cardiac sodium channel: Implications for arrhythmogenesis: Dr Samantha Salvage, University of Cambridge, UK
Structural insight to sodium channel function: Dr Altin Sula, Birkbeck, University of London, UK

Conceptual Learning in Physiology

Organised by Dr Sheila Amici-Dargan, University of Bristol, UK

This symposium will introduce you to an established evidence-based model, the EAT framework (Evans 2016), which can be used to design high-quality assessments that are both efficient and effective. There is a growing feeling amongst our learning community that poorly designed assessments may be disadvantaging some of our learners. Open-book assessments, for example, evaluate a totally different skills set compared to traditional ‘sit-down’ timed exams. In this rapidly evolving HE landscape we must constantly re-evaluate our teaching and assessment, to ensure we are developing the disciplinary and transferable skills in our students that are highly sought after by employers. The role of authentic teaching and assessments in supporting students to become self-regulated, conceptual learners will also be explored, as will the emerging impacts of digital technology and blended learning on staff and students. This symposium will provide tools for you to take away and use in your institution, to evaluate and develop self-regulation in your own students and develop high-quality authentic physiology assessments.

Supported by ADInstruments

Students as co-researchers and developers of assessment practice: Dr Sheila Amici-Dargan, University of Bristol, UK
Effectiveness = Efficiency and Quality: Professor Carol Evans, Cardiff University, UK
Poacher turned gamekeeper: Assessment criteria and peer-marking: Professor Jeremy Pritchard, University of Birmingham, UK
Supporting conceptual learning through authentic teaching and assessment: Professor Stephen Rutherford, University of Cardiff, UK

Metabolic and Endocrine Influences of the Menstrual Cycle and Hormonal Contraceptives: Methodological Considerations for Research in Eumenorrheic Females

Organised by Dr Juliette Strauss, Liverpool John Moores University, UK and Dr Kirsty Elliot, Nottingham Trent University, UK

Females are underrepresented in sport and exercise scientific research. Whilst in some cases sociocultural issues may explain this underrepresentation, it is anecdotally reported that this research is avoided due to the complexities of the menstrual cycle. This is avoidable however it is critical that any research in women withstands the same scientific rigor as research in males. Here we discuss some of the main considerations when conducting research in females, specifically exploring the effects to the endocrine system and substrate metabolism resulting from the changing hormonal milieu over the course of the menstrual cycle.

Overcoming amenorrhea in athletes with high training loads: Dr Jose Areta, Liverpool John Moores University, UK
The next step in female research: Endocrine and methodological considerations for research in eumenorrheic females: Dr Kirsty Elliott-Sale, Nottingham Trent University, UK
Oral contraceptive use and substrate metabolism during endurance exercise in women: Dr Laurie Isacco, University of Bourgogne Franche-Comte, Besançon, France
The influence of the menstrual cycle on substrate metabolism during exercise: Applications for female athletes: Dr Tanja Oosthuyse, The University of the Witwatersand, Johannesburg, South Africa

TMEM16: New Insights into Transmembrane Proteins of Broad Physiological Relevance in Health and Disease

Organised by Dr Mike Gray, Newcastle University, UK and Professor Karl Kunzelmann, University of Regensburg, Germany

The TMEM16 family of transmembrane proteins have wide tissue expression and participate in numerous physiological functions including epithelial secretion, smooth muscle contraction, nociception and phospholipid transport. There is also increasing evidence that dysfunction in TMEM16 proteins (acquired or inherited) is linked to important clinical diseases such as asthma, cancer and bleeding disorders. This symposium will highlight how current research is providing exciting new insights into how these proteins function as calcium-dependent ion channels and lipid transporters, and how this information is leading to the development of new therapeutic strategies for important human diseases.

Structural and functional characterisation of the lipid scramblase TMEM16F: Carolina Alvadia, University of Zurich, Switzerland
The pros and cons of targeting TMEM16A in cystic fibrosis: Professor Karl Kunzelmann, University of Regensburg, Germany
Functional expression of TMEM16A in taste bud cells: Professor Anna Menini, International School for Advanced Studies, Trieste, Italy
Functional coupling between TRPV1 and ANO1 in sensory neurons requires ER Ca2+ release: Dr Shihab Shah, University of Leeds, UK

PC001 Angiotensin receptor clustering and hypoxic remodelling in O2 sensitive cells

Hayyaf S. Aldossary^{1, 2}, Abdulaziz A. Alzahrani^{1, 3}, Deirdre Kavanagh⁴, Nikolaos Batis⁵, Clare J Ray¹, Prem Kumar¹, Andrew M. Coney¹, Andrew P. Holmes¹

¹Institute of Clinical Sciences, University of Birmingham, United Kingdom ²College of Medicine, Basic Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia ³Respiratory Care Department, Umm Al-Qura University, Saudi Arabia ⁴The Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, United Kingdom ⁵Institute of Cancer and Genomic Sciences, University of Birmingham, United Kingdom

PC002 Cycle length dependence of electrical and mechanical alternans in guinea pig ventricular myocytes

Alexander Carpenter¹, Andrew Butler¹, Julian Paton², Jules C Hancox¹, Andrew James¹¹University of Bristol, United Kingdom ²The University of Auckland, Auckland, New Zealand

PC003 Acute modification of upper-limb perfusion in vivo evokes a Prompt Adaptive Hemodynamic Response to re-establish cardiovascular homeostasis

Margarida Florindo¹, Sérgio Nuno², Sérgio Andrade³, Clemente Rocha³, Luís Monteiro Rodrigues³¹Universidade Lusófona CBIOS – Research Center for Biosciences and Health Technologies, Lisboa, Portugal 2 ESSCVP the Portuguese Red Cross Health School. Dep. Physiotherapy | Lisboa, Portugal ²Universidade Lusófona CBIOS – Research Center for Biosciences and Health Technologies, Lisboa, Portugal; Clínica S João de Deus – CTD | Lisboa Portugal; Escola Superior de Tecnologia da Saúde de Lisboa –ESTeSL Lisboas’ Polytechnic Institute | Lisboa, Portugal ³Universidade Lusófona CBIOS – Research Center for Biosciences and Health Technologies, Lisboa, Portugal

PC004 Pathological turret mutations in the cardiac sodium channel Nav1.5 induce long-range disruption to the pore geometry

Zaki F Habib^{1, 2}, Manas Kohli^{2, 3}, Samantha C Salvage², Taufiq Rahman³, Christopher L-H Huang^{1, 2}, Antony P Jackson²¹Department of Physiology, Development and Neuroscience, University of Cambridge, United Kingdom ²Department of Biochemistry, University of Cambridge, United Kingdom ³Department of Pharmacology, University of Cambridge, United Kingdom

PC005 Autonomic nervous system response to facial cooling increases velocity of left ventricle contraction and aortic compliance measured by pulse wave analysis

Agata Janczak¹, Beniamin Abramczyk²¹Department of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Poland ²Institute of Evolutionary Biology, University of Warsaw, Poland

PC006 Lysosomal calcium release modulates β-adrenergic response and arrhythmogenicity in ventricular cardiomyocytes by increasing SERCA activity

Zhao Meng¹, Rebecca A Capel¹, Samuel J Bose¹, Alfonso Bueno-Orovio², Rebecca A.B. Burton¹¹Department of Pharmacology, University of Oxford, United Kingdom ²Department of Computer Science, University of Oxford, United Kingdom

PC007 Transcriptional profiles of genes related to electrophysiological function in Scn5a+/- murine hearts

Michael Takla¹, Charlotte Edling¹, Kevin Zhang¹, Khalil Saadeh^{1, 2}, Gary Tse³, Samantha C Salvage⁴, Christopher L-H Huang⁴, Kamalan Jeevaratnam¹¹Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom ²School of Clinical Medicine, University of Cambridge, United Kingdom ³Xiamen Cardiovascular Hospital Affiliated to Xiamen University, China ⁴Physiological Laboratory, University of Cambridge, United Kingdom

PC008 The role of cardiopulmonary exercise testing (CPET) in predicting mortality and morbidity in people with congenital heart disease: a systematic review and meta-analysis

Curtis Wadey¹, Max Weston^{1, 2}, Dan-Mihai Dorobantu^{1, 3}, Guido Pieles^{4, 5}, Graham Stuart^{4, 6}, Alan Barker¹, Rod Taylor⁷, Craig Williams¹¹Children’s Health & Exercise Research Centre (CHERC), University of Exeter, United Kingdom ²School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Australia ³School of Population Health Sciences, University of Bristol, United Kingdom ⁴National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Centre, Bristol Heart Institute, United Kingdom ⁵Institute of Sport Exercise and Health (ISEH), University College London, United Kingdom ⁶Bristol Congenital Heart Centre, The Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, United Kingdom ⁷MRC/CSO Social and Public Health Sciences Unit & Robertson Centre for Biostatistics, Institute of Health and Well Being, University of Glasgow, United Kingdom

PC009 Student evaluation: Changes to a physiology module in response to COVID-19

Caitlin Smith¹, Gwen Hughes¹¹University of Nottingham, United Kingdom

PC010 Perception about teaching and learning methodologies applied in physiology, a study on medical students of Pakistan

Dr Qudsia Umaira Khan¹, Hameyl Tahir², Abdur Rafae Ahmad³¹CMH Lahore Medical college and IOD, Pakistan ²Lahore, Pakistan ³Lahore, Pakistan

PC011 Physiology education in Nigeria: Faculty opinions on challenges and suggested solutions

Oluwatosin Imoleayo Oyeniran¹, Terkuma Chia¹¹Nile University of Nigeria, Abuja, Nigeria

PC012 Assessment of repeatability using structured light plethysmography technique compared to spirometry

Eyas A. Alhuthail^{1, 2}, Brendan G. Cooper^{1, 3}, James A. Stockley³, Andrew M. Coney¹¹Institute of Clinical Sciences, University of Birmingham, United Kingdom ²College of Sciences and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia ³Lung Function and Sleep, University Hospitals Birmingham NHS Foundation Trust, United Kingdom

PC013 Influence of posture on the foot perfusion in the upright position

Sérgio Nuno^{1, 2, 3}, Tiago Atalaia^{4, 5}, Margarida Florindo^{1, 4}, Tiago Granja¹, João Abrantes⁵, Luís Monteiro Rodrigues¹¹Universidade Lusófona CBiOS (Research Center for Biosciences and Health Technologies), Lisboa, Portugal ²ESTeSL-IPL Escola Superior de Tecnologia da Saúde de Lisboa – Instituto Politécnico de Lisboa, Portugal ³Clínica São João de Deus – CTD, Lisboa, Portugal ⁴ESSCVP Escola Superior de Saúde da Cruz Vermelha Portuguesa – Lisboa, Portugal ⁵CICANT/MovLab, Universidade Lusófona, Lisboa, Portugal

PC014 Evaluating the efficacy of primary dysmenorrhoea management methods and their accessibility under universal health coverage

Abigail Prescott¹, Ourania Varsou¹¹University of Glasgow, United Kingdom

PC015 Microbial-metabolite pathways associated with cervicovaginal infection and spontaneous preterm birth: A systematic review

Neha Kulkarni¹, Emmanuel Amabebe¹, Megan Cavanagh¹, Dilly Anumba¹¹University of Sheffield, United Kingdom

PC016 Glucagon-like peptide 1 (GLP-1) secretion from gut endocrine cells is pH dependent

Malgorzata Cyranka¹, Natascia Vedovato¹, Heidi de Wet¹¹University of Oxford, United Kingdom

PC017 Transcriptome and methylome of the term human placenta in gestational diabetes mellitus: A systematic review and meta-analysis

Marta Ibañez Lligoña¹, Xiaohui Zhao¹, Alexandre G Torres², Tatiana El-Bacha³, Amanda Sferruzzi-Perri¹¹Department of Physiology, Development & Neuroscience, University of Cambridge, United Kingdom ²Institute of Chemistry, Federal University of Rio de Janeiro, Brazil ³Institute of Nutrition, Federal University of Rio de Janeiro, Brazil

PC018 Carotid body modulation decreases weigh gain and reverts dysmetabolism by ameliorating adipose tissue function and restoring sympathetic integration

Bernardete F. Melo¹, Joana F. Sacramento¹, Julien Lavergne², Daniela Rosendo-Silva³, Fatima O. Martins¹, Paulo Matafome^{3, 4, 5}, Elena Olea⁶, Cláudia S. Prego¹, Aidan Falvey², Philippe Blancou*², Silvia V. Conde*¹¹CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Portugal ²Université Côte d’Azur, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France ³Institute of Physiology and Institute of Clinical and Biomedical Research (iCBR), Coimbra, Portugal ⁴Clinical-Academic Center of Coimbra, Portugal ⁵Instituto Politécnico de Coimbra, Portugal ⁶Universidad de Valladolid, Instituto de Biología y Genética Molecular, Portugal

PC019 Identification of novel human gut microbiota metabolites from cyanidin- and delphinidin-type anthocyanins

Jasmine Percival¹, Mark Philo¹, Johanna Jokioja², Marianne Defernez¹, Perla Troncoso Rey¹, Wendy Hollands¹, Emad Shehata¹, Priscilla Day-Walsh¹, Lee Kellingray¹, Paul Needs¹, Arjan Narbad¹, Paul Kroon¹¹Quadram Institute Bioscience, Norwich, United Kingdom ²University of Turku, Turku, Finland

PC020 Effect of BMI on the motor nerve conduction study among medical students of AL-Neelain University

Tasneem El mekki¹, Tasabeeh Alnoor¹, Rama Musa¹, Lamis Kaddam¹, Humeda Suekit²¹Alneelain University , Khartoum, The Sudan ²International University of Africa, Khartoum, The Sudan

PC021 Psychoneuroimmunology of meditation

Dipti Magan¹¹Bathinda, Punjab, India

Student Learning in the Fourth Industrial Revolution: Why Attend Class when it’s all Online?

Is classroom attendance needed to acquire and apply knowledge? Can we guarantee that students learning elsewhere continue to learn and join a community of practice? Join in, hear about the most recent results from the USA, and help design future educational research for the UK.

Speakers:

Dr Harry Witchel, Brighton and Sussex Medical School, UK
Dr Christine A. Kauffman, University of Central Florida, Orlando, Florida
Professor Dee Silverthorne, The University of Texas at Austin, USA

Breakout Room Facilitators:

Dr Harry Witchel, Brighton and Sussex Medical School, UK
Dr Christine A. Kauffman, University of Central Florida, Orlando, Florida
Dr Rachel Ashworth, Queen Mary University of London, UK
Dr Etain Tansey, Queens University Belfast, UK
Dr Ruth Norman, University of Leeds, UK

Hidden clocks: Circadian rhythms and the vulnerable fetus

Professor Laura Bennet, University of Auckland, New Zealand

Seeing, Feeling, and Hearing Electrophysiology in Excitable Organs: Next-generation Electrophysiology

Organised by Dr Callum Zgierski-Johnston, Universitäts-Herzzentrum, Freiburg, Germany and Dr Rachel Myles, University of Glasgow, UK

For publication in Experimental Physiology.

Electrical activity of excitable organs such as the heart and brain is one of the fundamental bases for life. However, many key areas, including the long-term role of membrane potential in cellular signalling, ways various cell populations interact, and how excitation propagates in 3D, have not been sufficiently addressed. These gaps in our knowledge can be at least partly attributed to a lack of suitable tools. In this session we bring together investigators pioneering cutting-edge approaches for studying electrophysiology – from the development of novel probes to establishing approaches for in vivo investigations of whole organs in 3D.

Supported by Digitimer

Real-time optical imaging of electrophysiology and tissue mechanics in beating hearts: Dr Jan Christoph, Max Planck Institute for Dynamics and Self Organisation, Göttingen, Germany
: Professor Evan Miller, University of California Berkeley, USA
Optoacoustic imaging of whole heart and brain function: Professor Daniel Razansky, ETH Zurich, Switzerland
Using light to study heterocellular contributions to cardiac electrophysiology: Dr Franziska Schneider-Warme, University of Freiburg, Germany

The Future of Targeting Glucagon-Like Peptide-1 Signalling in Obesity Treatment: New Insights from Physiology

Organised by Professor Stefan Trapp, University College London, UK and Professor David Hodson, University of Birmingham, UK

Our body utilises glucagon-like peptide-1 (GLP-1) as both a gut hormone and a neuropeptide with both implicated in the regulation of food intake. GLP-1 receptor agonists (GLP-1RAs) are arguably set to become the most efficacious pharmacological obesity treatment, and yet we are still learning about where and how GLP-1 signals in the brain and periphery. This symposium brings together experts on GLP-1RA development, brain-derived GLP-1, gut-to-brain vagal signalling, and GLP1R detection/visualisation, to provide a comprehensive update of the latest developments in this exciting and translationally important field.

Research tools to visualise and interrogate the glucagon-like peptide 1 receptor: Dr Julia Ast, University of Birmingham, UK
GLP-1 receptor agonists: Mechanisms relevant for the treatment of obesity: Dr Lotte Bjerre-Knudsen, Novo Nordisk, Bagsværd, Denmark
Central and peripheral glucagon-like peptide-1 systems independently suppresses eating: Dr Daniel Brierley, University College London, UK
Elucidating the molecular mechanisms required for vagally-mediated physiological response to peripheral GLP1: Dr Guillaume De Lartigue, University of Florida, USA

The Many Facets of the Microcirculation in Health and Disease

Organised by Dr Jacqueline Whatmore, University of Exeter, UK and Dr Neena Kalia, University of Birmingham, UK

For publication in The Journal of Physiology.

Pathophysiological disturbances in the microcirculation is a key feature of many common diseases. This symposium aims to highlight latest discoveries in the basic biology of microcirculatory regulation and how things can go drastically wrong in this microvascular compartment. Speakers will cover the role of the microcirculation in a broad range of diseases including acute renal injury, diabetes, myocardial infarction and Alzheimer’s disease, presenting both experimental and clinical research. Furthermore, this symposium will present novel technical advancements in the imaging of microcirculatory processes in vivo and how they are reshaping microcirculation research.

Microvascular actions of the dipeptidyl peptidase-IV inhibitor, vildagliptin, in obesity: Dr Kim Gooding, University of Exeter, UK
Imaging the glomerulus to understand leukocyte function during glomerulonephritis: Professor Michael Hickey, Monash University, Australia
Imaging the injured and aged coronary microcirculation in vivo in the murine beating heart : Dr Neena Kalia, University of Birmingham, UK
BACE1: A novel regulator of the microcirculation from head to toe: Dr Paul Meakin, University of Leeds, UK

PC022 Chronic intermittent hypoxia in utero depresses basal carotid body activity and hypoxic sensitivity in adult offspring

Abdulaziz A. Alzahrani^{1, 2}, Andrew P. Holmes^{1, 3}, Hayyaf S. Aldossary^{1, 4}, Agnieszka Swiderska⁵, Clare J Ray¹, Prem Kumar¹, Andrew M. Coney¹¹Institute of Clinical Sciences, University of Birmingham, United Kingdom ²Respiratory Care Department, Umm Al-Qura University, Makkah, Saudi Arabia ³Institute of Cardiovascular Sciences, University of Birmingham, United Kingdom ⁴Basic Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia ⁵Institute of Cardiovascular Sciences, The University of Manchester, United Kingdom

PC023 Cardiac troponin T amino terminus is required for inhibition of Ca2+- dependent sliding of thin filaments

Linda Stroud¹, Vincent A. LaBarbera¹, Fang Wang¹, Lauren E. Kessler¹, Brenda Schoffstall², P. Bryant Chase¹¹Florida State University, The United States of America ²Barry University, Florida, The United States of America

PC024 Regular walking significantly improves foot perfusion independently of age

Margarida Florindo¹, Sérgio Nuno², João Gregório³, Luís Monteiro Rodrigues³¹CBIOS – Research Center for Biosciences and Health Technologies, Universidade Lusófona, Lisboa, Portugal; ESSCVP the Portuguese Red Cross Health School. Dep. Physiotherapy, Lisboa, Portugal ²CBIOS – Research Center for Biosciences and Health Technologies, Universidade Lusófona, Lisboa, Portugal; Clínica S João de Deus – CTD | Lisboa Portugal ; ESTeSL Lisboas’ Polytechnic Institute | Lisboa, Portugal , Lisboa, Portugal ³CBIOS – Research Center for Biosciences and Health Technologies, Universidade Lusófona, Lisboa, Portugal

PC026 Does a reduction in Nav1.5 protein expression within the right atria increase an elderly patient’s susceptibility to atrial fibrillation?

Emmanuel Isaac¹, Matthew Lancaster², Mahmoud Loubani³, Sandra Jones¹¹University of Hull, United Kingdom ²University of Leeds, United Kingdom ³University of Hull Teaching Hospital, United Kingdom

PC027 Reliable identification of cardiac liability in drug discovery using automated patch clamp: Considerations and best practices for high throughput recordings of NaV1.5

Alison Obergrussberger¹, Maria Giustina Rotordam¹, Nina Brinkwirth¹, Kiyoshi Takasuna², Nadine Becker¹, András Horváth¹, Hatsue Furukawa², Yuka Hasegawa², Takayuki Oka³, Niels Fertig¹, Sonja Stoelzle-Feix¹¹Nanion Technologies GmbH, Munich, Germany ²Axcelead Drug Discovery Partners, Inc., Fujisawa, Japan ³Nanion Technologies K.K, Tokyo, Japan

PC028 Carbon nanotube-based scaffolds for cardiac tissue engineering – Systematic review and narrative synthesis

Louie Scott¹, Izabela Jurewicz², Kamalan Jeevaratnam¹, Rebecca Lewis¹¹Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom ²University of Surrey, Guildford, United Kingdom

PC029 Noradrenaline stimulates human atrial L-type Ca2+ current by activating β1-adrenoceptors, and to a smaller degree α1, with a mixed and minor contribution from β2 and α2

Priyanka Saxena¹, Rachel Myles¹, Godfrey Smith¹, Antony Workman¹¹University of Glasgow, United Kingdom

PC030 Assessment of hair cortisol in euthyroid, hypothyroid, and subclinical hypothyroid subjects

Darya Abdulateef¹, Taha Mahwi¹¹University of Sulaimani, College of Medicine, Iraq

PC031 Modulation of L-type voltage-gated calcium channels interferes with intracellular calcium mobilisation in mouse white fat adipocytes

Nneoma E. Akaniro-Ejim¹, Paul A. Smith¹¹University of Nottigham, Nottingham, United Kingdom

PC032 Vitamin D receptor activation exerts anti-secretory actions in colonic epithelial cells

Caitriona E. Curley¹, Stephen J. Keely¹¹The Royal College of Surgeons, Dublin, Ireland

PC033 Vaginal chemokine delivery system for pelvic floor muscular dysfunction and urinary incontinence prophylaxis and therapy

Juliana Ferreira Floriano^{1, 2}, Sofia Vega¹, Angélica Barbosa^{1, 3}, Luis Sobrevia^{1, 4, 5, 6, 7}, Marilza Vieira Rudge¹¹Botucatu Medical School – Sao Paulo State University, Brazil ²National Heart and Lung Institute, Imperial College London, United Kingdom ³Department of Physiotherapy and Occupational Therapy, São Paulo State University (UNESP), Marilia, Brazil ⁴Cellular and Molecular Physiology Laboratory (CMPL), Pontificia Universidad Católica de Chile, Santiago, Chile ⁵Department of Physiology, Universidad de Sevilla, Spain ⁶University of Queensland Centre for Clinical Research, Australia ⁷University Medical Center Groningen, The Netherlands

PC034 Carotid body chemosensitivity at rest and during exercise in patients with hypertension

Katrina Hope¹, Angus K. Nightingale¹, Julian Paton², Emma C. Hart¹¹Universtiy of Bristol, United Kingdom ²The University of Auckland, New Zealand

PC035 Observations on the interaction between perfusion and postural stability in both feet during movement

Sérgio Nuno^{1, 2, 3}, Tiago Atalaia^{4, 5}, Margarida Florindo^{1, 4}, Tiago Granja¹, João Abrantes⁵, Luís Monteiro Rodrigues¹¹Universidade Lusófona CBiOS (Research Center for Biosciences and Health Technologies), Lisboa, Portugal ²ESTeSL-IPL Escola Superior de Tecnologia da Saúde de Lisboa – Instituto Politécnico de Lisboa, Lisbon Polytechnic Institute – Lisboa, Portugall ³Clínica São João de Deus – CTD, Lisboa, Portugal ⁴ESSCVP Escola Superior de Saúde da Cruz Vermelha Portuguesa – Lisboa, Portugal ⁵CICANT/MovLab, Universidade Lusófona, Lisboa, Portugal

PC036 Continuous compared to accumulated multicomponent-training on physical function and health-related quality of life in sedentary elderly

Pablo Monteagudo^{1, 2}, Ainoa Roldán¹, Ana Cordellat¹, Jordi Monferrer-Marín¹, M Carmen Gómez-Cabrera³, Cristina Blasco-Lafarga¹¹Physical Education and Sport Department, University of Valencia, Spain ²Department of Education and Specific Didactics, Jaume I University, Castellón de la Plana, Spain ³Physiology Department, University of Valencia, Spain

PC037 The Effect of Gum Arabic Supplementation on Cathelicidin expression in Monocyte Derived Macrophages in Mice

Nagat bashir¹, Rehab Badi², Tahani Mohammeddeen³, Khalid Enan⁴, Amal Saeed⁵¹Department of Physiology, Red Sea University, Portsudan, The Sudan. ² Department of Physiology, King Khalid University, Saudi Arabia ³Department of Microbiology, Red Sea University, Portsudan, The Sudan ⁴Department of Virology, Ministry of Higher Education and Scientific Research, Department Khartoum, The Sudan ⁵Department of Physiology, Faculty of Medicine, University of Khartoum, The Sudan

PC038 Influence of season on the modulating role of ascorbic acid and L-carnitine on respiratory rate of African giant rats (cricetomys gambianus, waterhouse - 1840)

Tavershima Dzenda¹, Joseph O. Ayo¹¹Ahmadu Bello University, Zaria, Nigeria

PC039 Physiology of body composition – how do vegetarians and omnivores differ?

Cíntia Ferreira-Pêgo¹, Rejane Giacomelli Tavares¹, Sofia Lopes², Tatiana Fontes², Luís Monteiro Rodrigues¹¹CBIOS – Universidade Lusófona’s Research Center for Biosciences & Health Technologies, Lisboa, Portugal ²School of Sciences and Health Technologies Universidade Lusófona de Humanidades e Tecnologias, Lisboa, Portugal

PC040 Anti-inflammatory and anti-oxidative properties of aqueous extract of Triticum aestivum (common wheat) on acetic acid-induced colitis in Wistar rats

Okwute Ochayi¹, Zaliha Umar¹, Emmanuel Ochai², Ojo Akanji¹, Grace-Gege Adebayo¹¹Baze University, Federal Capital Territory, Nigeria ²Ahmadu Bello University, Zaria, Nigeria

PC041 Evaluating the leucine trigger hypothesis to explain the postprandial regulation of muscle protein synthesis in young and older adults: A systematic review

Gabriele Zaromskyte¹, Konstantinos Prokopidis², Theofilos Ioannidis¹, Kevin D Tipton³, Oliver C Witard⁴¹Department of Nutritional Sciences, King’s College London, United Kingdom, United Kingdom ²Institute of Life Course and Medical Sciences, University of Liverpool, United Kingdom ³Institute of Performance Nutrition, London, United Kingdom ⁴Centre for Human and Applied Physiological Sciences, King’s College London, United Kingdom

PC042 Mapping the daily rhythmic transcriptome in the diabetic retina

Eleni Beli¹, Ryan Silk¹, Vijay Tiwari¹, David Simpson¹, Alan Stitt¹¹Queen’s University Belfast, United Kingdom

PC043 In Silico Investigation on possible involvement of neuroendocrine modulations in diabetic peripheral neuropathy

Arif Kamil Salihoglu¹¹Karadeniz Technical University, Trabzon, Turkey

Cardiac & Vascular Physiology B

14:00 OC25 Respiratory coupling of muscle sympathetic nerve activity in healthy postmenopausal women and young adults: Zoe H Adams, University of Bristol, United Kingdom
14:15 OC26 Vertebral artery hypoplasia and brainstem blood flow in patients with hypertension: Bleddyn Woodward, Cardiff University, United Kingdom
14:30 OC27 The response of atrial pacemaker activity to α-adrenergic stimulation is inhibited by the type 1 adenylyl cyclase inhibitor ST034307: Samuel J Bose, University of Oxford, UK
14:45 OC28 An organelle proteomics method to study endolysosomal proteins in a goat model of atrial fibrillation: Thamali Ayagama, University of Oxford, United Kingdom
15:00 OC29 A novel SCN3b mutation in a Brugada Syndrome patient: Sahib S Sarbjit-Singh, University of Cambridge, United Kingdom
15:15 OC30 Evaluation of the murine experimental model of senescence SAMR1/SAMP8 for microRNA studies in Acute Myocardial Infarction: Professor Susana Novella, INCLIVA Biomedical Research Institute, Valencia, Spain and University of Valencia, Spain

Epithelia & Membrane Transport A

14:00 OC31 Functional analysis of two epithelial sodium channel isoforms in rodents: Sean Gettings, Newcastle University, United Kingdom
14:15 OC32 Neuropeptide W (NPW) treatment ameliorates acetic acid-induced colonic injury in rats by upregulating colonic blood flow and depressing cyclooxygenase-2 expression: Sevil Arabacı Tamer, Marmara University, Istanbul, Turkey and Sakarya University, Turkey
14:30 OC33 Regulation of the cystic fibrosis transmembrane conductance regulator (CFTR) by the nuclear bile acid receptor, farnesoid X receptor: Jessica S Smyth, Royal College of Surgeons in Ireland, Dublin, Ireland
14:45 OC34 Impact of the F508del mutation on pig cystic fibrosis transmembrane conductance regulator (CFTR), a Cl- channel with enhanced ATP-dependent channel gating: Demi R S Ng, University of Bristol, United Kingdom
15:00 OC35 Potential targets for underactive bladder treatments: Receptor-mediated contractions of the urinary bladder urothelium: Charlotte Phelps, Bond University, Gold Coast, Australia

Human, Environmental & Exercise Physiology A

14:00 OC36 Physiology students can use a quality improvement approach to support a safe and efficient medication pathway in geriatric rehabilitation: Professor Derek Scott, University of Aberdeen, United Kingdom
14:15 OC37 Effect of high intensity interval exercise on BDNF isoforms and cognitive function in patients with type 2 diabetes: Ramlah M Farouk, Yusuf Maitama Sule University, Kano, Nigeria
14:30 OC38 A proof-of-concept experimental study to quantify lobar gas exchange: Jack Gallifant, King’s College London, United Kingdom
14:45 OC39 The mediating role of endocrine factors in the positive relationship between fat mass and bone mineral content in children aged 9-11 years: The physical activity and nutrition in childhood study: Annie M Constable, University of Exeter, UK and University of Eastern Finland, Kuopio, Finland
15:00 OC40 Remote teaching and learning in Higher Education: A cross-sectional survey on the impact on physical activity and health-related quality of life of staff and students: Dr Faatihah Niyi-Odumosu, University of the West of England, Bristol, United Kingdom

Regulation of blood flow at the capillary level in health and disease

Professor David Attwell, University College London, UK

The gut endocrine axis in the control of metabolism

Professor Fiona Gribble, University of Cambridge, UK

Decoding Prefrontal Cortical Physiology: Circuits of Cognition

Organised by Professor Matthew Jones, University of Bristol, UK and Dr Abhishek Banerjee, Newcastle University, UK

For publication in The Journal of Physiology.

The prefrontal cortex (PFC) is a central hub of cognition, flexibly integrating, processing and routing information according to external demands and internal state. How does PFC physiology enable such dynamic and diverse roles?

This symposium unites early-career and experienced researchers harnessing rodent and non-human primate models to understand the roles of the PFC in behaviour by studying the connectivity, plasticity, computations, and behavioural contributions of PFC circuits. Our aim is to spark discussion about how developmental principles lead to complex computations, helping to link neurophysiologists working across different levels of analysis and guide future efforts to decode PFC physiology.

Prefrontal thalamocortical connectivity: Cracking the circuitry of cognition: Dr Paul Anastasiades, University of Bristol, UK
Cognitive switches and value-guided remapping in cortical circuits: Professor Abhishek Banerjee, Newcastle University, UK
Evidence of neural interactions between the mediodorsal thalamus and orbitofrontal cortex during visuospatial discrimination learning in macaques: Professor Anna Mitchell, University of Oxford, UK
Heterogeneity of function within primate ventromedial prefrontal cortex: Professor Angela Roberts, University of Cambridge, UK

Dissecting Interactions Regulating the Thyroid by Functional Imaging and Manipulation

Organised by Dr Paul Le Tissier, University of Edinburgh, UK

This symposium will describe cutting edge research that is revealing the dynamic interactions between the hypothalamus, pituitary and thyroid that regulates the output of thyroid hormone. Despite the clinical relevance of the thyroid axis, it is perhaps the least understood in terms of hypothalamic and pituitary regulation. The use of animal models, genetic targeting and imaging of cell function is now allowing a clearer understanding of the complex feedforward and feedback mechanisms involved in both normal physiology and in disease, with important implications for diagnosis and treatment of dysregulation.

Imaging TSH receptor signalling and internalisation: Professor Davide Calebiro, University of Birmingham, UK
Thyroid hormone transporters within the hypothalamus-pituitary-thyroid axis: Professor Dr Heike Heuer, University of Duisburg-Essen, Germany
Revealing a modular network of committed pituitary thyrotrophs in health and disease: Yasmine Kemkem, Institut Génomique Fonctionnelle, Montpellier, France
An update of key morphogenetic events of thyroid development in Zebrafish: Dr Federica Marelli, IRCCS Istituto Auxologico Italiano, Milan, Italy

Microbiomes in Physiology

Organised by Dr Priscilla Day-Walsh, Quadram Institute, Norwich, UK and Emad Shehata, Quadram Institute, Norwich, UK

The microbiome has emerged as critical to physiological homeostasis, influencing health and disease status in the host. Microbial effects on physiology can be acute (e.g infections caused by bacteria and viruses that can in extreme cases cause sepsis and death). However, they can also be subtle but chronic subsequently leading to metabolic diseases such as diabetes, cardiovascular disease, and neurodegenerative diseases. The symposium will address the chronic physiological effects of the microbiome focusing on the gut-liver, gut-heart, and gut-brain axes. Will discuss future therapeutic targets that can enhance the growth of beneficial microbiota to prevent metabolic diseases.

Gut microbiota regulate hallmarks of inflammageing: Dr Aimee Parker, Quadram Institute Biosciences, UK
Probiotics alter the antibiotic resistance gene reservoir along the human GI tract: Dr Jotham Suez, Weizmann Institute of Science, Rehovot, Israel
The interplay between the microbiome and the mammalian host across the lifecourse and its influence on host physiology and metabolic disease: Professor Jonathan Swann, University of Southampton, UK
The gut-heart axis : Professor Toru Suzuki, University of Leicester, UK

Skeletal Muscle from Molecules to Movement

Organised by Dr Gladys Pearson, Manchester Metropolitan University, UK and Professor Hans Degens, Manchester Metropolitan University, UK

Muscles are indispensable for locomotion. However, during our lifetime they are exposed to many potentially deleterious factors, including reactive oxygen species that may cause muscle damage. Part of the reactive oxygen species may come from dysfunctional mitochondria, and particularly smoking can have a detrimental impact on mitochondrial function. This oxidative stress may also affect the neuromuscular interaction and over time result in an age-related loss of motor neurons and muscle wasting. To overcome this problem, there is much interest in the muscle response to exercise to perhaps combat the age-related muscle wasting. This symposium brings together researchers who will focus on various aspects of this muscle damage and approaches to counteract the loss in function.

Supported by Digitimer

: Dr Carolyn Greig, University of Birmingham, UK
Muscle damage and reactive oxygen species: Professor Malcolm Jackson, University of Liverpool, UK
Age-related muscle atrophy: A battle of nerves?: Dr Mathew Piasecki, University of Nottingham, UK
From cigarette smoking to burning mitochondria: Professor Rob Wüst, Vrije University Amsterdam, The Netherlands

PC044 Biochemical signalling pathways are disrupted in the myocardium of mdx 5cv mice and not rescued by ΔR4-R23/ΔCT micro-dystrophin

Daniel Brayson¹, Elena Marrosu¹, Charlotte Scott¹, Hong Wang^{2, 3}, Nalinda Wasala⁴, Dongsheng Duan^{4, 5}, Federica Montanaro^{1, 2}¹UCL Great Ormond Street Institute of Child Health, London, United Kingdom ²The Research Institute at Nationwide Children’s Hospital, Columbus, The United States of America ³Shengjing Hospital, China Medical University, Liaoning, China ⁴Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, The United States of America ⁵Department of Neurology, School of Medicine; Department of Bioengineering, and Department of Biomedical Sciences, College of Veterinary Medicine; and Department of Biomedical, Biological & Chemical Engineering, College of Engineering, University of Missouri, The United States of America

PC045 Palmitoylation and regulation of the “funny” current HCN4 channel

Samitha Dilini Congreve^{1, 2}, Alice Main¹, Andrew Butler², Elaine Brown¹, Jules C Hancox², William Fuller¹¹Institute of Cardiovascular & Medical Sciences, University of Glasgow, United Kingdom ²School of Physiology, Pharmacology and Neuroscience, University of Bristol, United Kingdom

PC046 Action potential clamp characterization of a short QT syndrome “hotspot” hERG mutation

Chunyun Du¹, Yihong Zhang¹, Christopher Dempsey², Henggui Zhang³, Stephen Harmer¹, Jules C Hancox¹¹Schools of Physiology and Pharmacology and Neuroscience, University of Bristol, United Kingdom ²Schools of Biochemistry, University of Bristol, United Kingdom ³School of Physics and Astronomy, University of Manchester, United Kingdom

PC047 LQTS-Associated calmodulin mutations disrupt interactions with the Kv7.1 voltage-gated potassium channel

Liam F McCormick¹, Nitika Gupta¹, Ohm Prakash¹, Caroline Dart², Nordine Helassa¹¹Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, United Kingdom ²Department of Molecular and Physiology Cell Signalling, Institute of Systems Molecular and Integrative Biology, University of Liverpool, United Kingdom

PC048 Computational study of SARS-CoV-2 infection inhibitor Hydroxychloroquine on Cardiac toxicity

Chitaranjan Mahapatra¹¹University of California San Francisco, The United States of America

PC048 Computational study of SARS-CoV-2 infection inhibitor Hydroxychloroquine on Cardiac toxicity

Chitaranjan Mahapatra¹¹University of California San Francisco, The United States of America

PC049 Vasorelaxation effect of oximes synthesised from hydroxyacetophenone and hydroxytremetone derivatives isolated of endemic medicinal plants of North Chile in rat aorta

Javier Palacios¹, Adrian Paredes², Marcelo A. Catalán³, Fredi Cifuentes⁴¹Departamento Química y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Iquique, Chile ²Departamento de Química, Facultad de Ciencias Básicas, Universidad de Antofagasta, Chile ³Instituto de Fisiología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile ⁴Laboratorio de Fisiología Experimental (EPhyL), Instituto Antofagasta (IA), Universidad de Antofagasta, Chile

PC050 The role of angiotensin II-mediated pericyte contractility in sensory neurodegeneration in diabetic neuropathic pain

Matthew Sheavyn¹, Lydia Hardowar¹, Richard Hulse¹¹Nottingham Trent University, United Kingdom

PC051 Investigation of effects of S5 mutation F557L on actions of selected non-canonical hERG potassium channel inhibitors

Yihong Zhang¹, Christopher Dempsey², Jules C Hancox¹¹School of Physiology, Pharmacology & Neuroscience, University of Bristol, United Kingdom ²School of Biochemistry, University of Bristol, United Kingdom

PC052 Causes and consequences of preterm birth

Javeria Malik¹, Nabila roohi²¹Lahore, Pakistan ²Lahore, Pakistan

PC053 A novel dietary intervention reduces circulatory branched-chain amino acids by 50%: A pilot study of relevance for obesity and diabetes

Imran Ramzan¹, Moira Taylor¹, Beth Philips¹, Daniel Wilkinson¹, Ken Smith¹, Kate Hession¹, Iskandar Idris¹, Philip Atherton¹¹University of Nottingham, Derby, United Kingdom

PC054 Identification of an epithelial cell line for two- and three-dimensional studies of intestinal ion transport

Bethan R Hawley¹, Tracey J Collard², Ann C Williams², David N Sheppard¹¹School of Physiology, Pharmacology & Neuroscience, University of Bristol, United Kingdom ²School of Cellular and Molecular Medicine, University of Bristol, United Kingdom

PC055 Adipose depot dependency of chloride channels expression in murine white fat

Yan Meng¹, Olena Fedorenko¹, Maria Toledo-Rodriguez ¹, Nneoma E. Akaniro-Ejim¹, Paul A. Smith¹¹University of Nottingham, United Kingdom

PC056 An investigation of the effects and mechanism of Adenocin triphosphate on pregnant human myometrial contractility

Hind Z¹, Helen Wallace¹¹University of Liverpool, United Kingdom

PC057 Systemic sex hormones do not explain resting fat oxidation or peak fat oxidation during exercise in women with varying menopausal states

Jari E. Karppinen¹, Hanna-Kaarina Juppi², Jukka Hintikka¹, Petri Wiklund^{1, 3, 4, 5}, Eero A. Haapala^{1, 6}, Matti Hyvärinen², Tuija Tammelin⁷, Pauliina Aukee⁸, Urho M. Kujala¹, Jari Laukkanen^{1, 9, 10, 11}, Eija K. Laakkonen²¹Faculty of Sport and Health Sciences, University of Jyväskylä, Finland ²Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Finland ³Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, United Kingdom ⁴Faculty of Medicine, University of Oulu, Finland ⁵The Exercise Translational Medicine Centre, Shanghai Jiao Tong University, China ⁶Faculty of Biomedicine, University of Eastern Finland, Kuopio, Finland ⁷LIKES Research Centre for Physical Activity and Health, Jyväskylä, Finland ⁸Department of Obstetrics and Gynecology, Pelvic Floor Research and Therapy Unit, Central Finland Central Hospital, Jyväskylä, Finland ⁹Institute of Clinical Medicine, Department of Medicine, University of Eastern Finland, Kuopio, Finland ¹⁰Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland ¹¹Department of Internal Medicine, Central Finland Healthcare District, Jyväskylä, Finland

PC058 Inhibitory activities of n-hexane fraction of Moringa oleifera leaves(Lam.) against phospholipases isolated from Naja haje and Naja nigricollisvenoms: in vitro and in silico

Adeyi Oluwatosin¹, Abideen Omobayo Jimoh ¹, Siji Ajisebiola², Esther Olubisi Adeyi³¹University of Ibadan, Nigeria ²Osun State University, Nigeria ³ Federal University of Agriculture, Abeokuta, Nigeria

PC059 Effect of a single session of exercise on salivary cytokines and salivary cortisol in young male judoists

Irina Shvydchenko¹, Sergey Sergeev¹¹Kuban State University of Physical Education, Sport and Tourism, Krasnodar, The Russian Federation

PC060 The modification of choline and betaine metabolism to TMA by the gut microbiota using polyphenol rich foods

Priscilla Day-Walsh¹, Emad Shehata^{1, 2}, Lee Kellingray¹, Arjan Narbad¹, Salvatore Rapisarda³, Paul Kroon¹¹Quadram Institute Bioscience, Norwich, United Kingdom ²National Research Centre, Cairo, Egypt ³Medinutrex – Mediterranean Nutraceutical Extracts, Italy

PC061 (-)-Epicatechin and its colonic metabolite hippuric acid protect against dexamethasone-induced atrophy in skeletal muscle cells

Sophie J Edwards¹, Steven Carter², Thomas Nicholson¹, Sophie L Allen ¹, Simon W Jones ¹, Catarina Rendeiro¹, Leigh Breen¹¹University of Birmingham, United Kingdom ²University of Bath, United Kingdom

PC062 Phoenixin 14 ameloriates pancreatic injury in streptozotocin induced diabetic rats by alleviating oxidative damage

Eminenur Şen¹, Hasan Basri Yapıcı¹, Ömer Faruk Domruk¹, Yusra Aldağ¹, Nurullah Atakul¹, Zarife Nigar Özdemir Kumral², Leyla Semiha Şen², Hatice Boracı¹, Fatma Kanpalta¹, Ozan Ünlü¹, Meral Yüksel³, Dilek Özbeyli⁴, Ural Verimli¹, Dilek Akakin⁵, Can Erzik⁶, Goncagül Haklar¹, Neşe İmeryüz¹¹Marmara University School of Medicine, Istanbul, Turkey ²Marmara University School of Medicine, Department of Physiology, Istanbul, Turkey ³Marmara University Institute of Health Sciences, Istanbul, Turkey ⁴Marmara University Institute of Health Sciences, Department of Physiology, Istanbul, Turkey ⁵Marmara University School of Medicine, Department of Histology and Embryology, Istanbul, Turkey ⁶Marmara University School of Medicine, Department of Medical Biology, Istanbul, Turkey

PC063 Pilot study on metabolic flexibility in elderly women: Preliminary results

Jordi Monferrer-Marín¹, Ainoa Roldán¹, Pablo Monteagudo^{1, 2}, Ana Cordellat¹, Iván Chulvi-Medrano¹, Cristina Blasco-Lafarga¹¹University of Valencia, Spain ²Jaume I University, Castellon, Spain

PC064 Retinoid X Receptor A (Exon 9) gene polymorphisms among healthy individuals of southern Pakistani population

Tayyaba Shah¹, Mehir un Nisa Iqbal¹, Taseer Ahmed Khan¹¹University of Karachi, Pakistan

PC065 Feedback loop switch model of fibromyalgia pathophysiology, first assessment by patient questionnaires

Ilaria Demori¹, Giulia Giordano², Fabio Rapallo³, Elena Molinari⁴, Viviana Mucci⁵, Lucio Marinelli⁶, Serena Losacco⁷, Paolo Massobrio⁸, Franco Blanchini⁹, Bruno Burlando⁷¹Department of Earth, Environmental and Life Sciences, University of Genova, Italy ²Department of Industrial Engineering, University of Trento, Italy ³Department of Economy, University of Genova, Genova, Italy ⁴Clinical Psychology Unit, EO Ospedali Galliera, Genova, Italy ⁵School of Science, Western Sydney University, Penrith, Australia ⁶Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Italy ⁷Department of Pharmacy, DIFAR, University of Genova, Italy ⁸Department of Informatics, Bioengineering, Robotics and Systems Engineering, University of Genova, Italy ⁹Department of Mathematics, Computer Science and Physics, University of Udine, Italy

PC066 A de novo variant in CROCC identified in a Chinese family implies the potential association with Atlanto-occipital Fusion (AOF)

Huaiyu Tong¹, Chongye Guo², Liang Liang³, Hua Mi⁴, Meng Li³, Yiheng Yin¹, Lijun Shang⁵, Shuangli Mi⁶, Xinguang Yu¹¹Chinese PLA General Hospital, Beijing, China ²The Center for Microbial Resource and Big Data, Chinese Academy of Sciences, Beijing, China ³Beijing Institute of Genomics, Chinese Academy of Sciences, China National Center for Bioinformation, China ⁴XuanWu TCM Hospital Beijing, China ⁵London Metropolitan University, United Kingdom ⁶University of Chinese Academy of Sciences, Beijing, China

Cardiac & Vascular Physiology C

14:00 OC42 Activation of Ano1 channels by Ca2+ signalling in interstitial cells of Cajal contributes to tone in the mouse and monkey lower esophageal sphincter: Dr Bernard Drumm, University of Nevada, The United States of America and Dundalk Institute of Technology, Ireland
14:15 OC43 Interaction of arrhythmia-associated calmodulin mutations with voltage-gated Ca2+ channel (Cav1.2) and Ca2+/CaM-dependent protein kinase II delta (CaMKIIδ): Ohm Prakash, University of Liverpool, United Kingdom
14:30 OC44 Small conductance Ca2+-activated K+ current (ISK) may not be activated by [Ca2+]i elevation in non-failing ventricular myocytes: Dr Antony Workman, University of Glasgow, United Kingdom
14:45 OC47 In Alzheimer’s disease, Amyloid Beta initiates small vessel disease through damage to resistance artery Ca2+ spark vasoregulation: Dr Harry Pritchard, University of Manchester, United Kingdom
15:00 OC46 Fast voltage-dependent sodium (NaV) currents are functionally expressed in mouse corpus cavernosum smooth muscle cells: Xin Rui Lim, Dundalk Institute of Technology, Ireland
15:15 OC45 Noradrenaline stimulates rabbit atrial L-type Ca2+ current via β1- and α1-adrenoceptors, attenuated by β2-activation, with a mixed and minor contribution from α2: Dr Antony Workman, University of Glasgow, United Kingdom

Endocrinology A

14:00 OC48 Extract of black sticky rice prevent hyperglycemia-induced developmental & motoric impairment during early development of zebrafish (Danio rerio): Dewi Mustika, Universitas Brawijaya, Malang, Indonesia
14:15 OC49 The effect of acute exercise in humans on cancer cell growth in vitro: Findings from a meta-analysis and crossover study: Dr Sam Orange, Newcastle University, United Kingdom
14:30 OC50 Carotid body modulation decreases weight gain and improves metabolic function in the rat by impacting feeding behaviour and hypothalamic satiety pathways: Adriana M Capucho, CEDOC, NOVA Medical School, Lisboa, Portugal
14:45 OC51 Erg channels control excitability in male murine anterior pituitary corticotrophs: Dr Sooraj Nair, University of Edinburgh, United Kingdom
15:00 OC52 Impact of carotid sinus nerve resection on glucose homeostasis and weight gain in mice: Is there a role for β2-adrenergic signalling?: Joana F Sacramento, CEDOC, NOVA Medical School, NOVA University Lisbon, Portugal
15:15 OC53 HIIT’ing or MISS’ing the optimal management of Polycystic Ovary Syndrome: A systematic review and meta-analysis of high- versus moderate-intensity exercise prescription: Cory Richards, Cardiff Metropolitan University, United Kingdom

Neuroscience B

14:00 OC54 A hypothalamic-hindbrain pathway that suppresses feeding following acute stress: Dr Marie Holt, University College London, United Kingdom and Florida State University, The United States of America
14:15 OC55 ß-alanine protects the brain tissue from ischemic damage: Sergiy Sylantyev, Rowett Institute, University of Aberdeen, United Kingdom
14:30 OC56 Psychological stress alters voiding behaviour and enhances activity in both low and high threshold bladder afferent nerves in female mice: Kylie Mills, Bond University, Gold Coast, Australia
14:45 OC57 Graded calcium spikes differentially signal neurotransmitter input in cerebrospinal fluid contacting neurons of mouse spinal cord: Emily Johnson, University of Leeds, United Kingdom
15:00 OC23 The role of the HCN channel receptor in neuropathic pain: A feasibility study of ivabradine in patients with chronic peripheral neuropathic pain: Shannon Bernard Healey, University of Cambridge, United Kingdom

Teaching Physiology: How to Prioritize Hands-On Labs and Learning for Students in Any Location

Increase student engagement in labs, at home, or in any remote location and learn about new options for physiology labs using Biopac Student Lab (BSL) and functional near infrared spectroscopy for education.

Biopac Student Lab introduces students to data collection and analysis in physiology, biology, biomedical engineering, pharmacology, toxicology, psychophysiology, and neurophysiology labs. BSL is a complete physiology lab solution with 1, 2 and 4 channel options with built-in lessons to save professor’s time. fNIRS for Education is the newest option and offers practical lab lessons focusing on muscle oxygenation and brain function.

Join BIOPAC to learn all about the BSL line and all the different ways it can improve your physiology lab.

Meet the Editors

Join this session and pose your questions to Professor Kim Barrett and Professor Michael Tipton, current Editors-in-Chief of The Journal of Physiology and Experimental Physiology.

Local iron homeostasis: Mechanisms, importance and implications

Professor Samira Lakhal-Littleton, University of Oxford, UK

Exercise, Stress and Mental Health: Moving from Current Biomarkers to a Role for the Microbiome-Gut-Brain-Axis

Organised by Dr Jason Martin, University College Cork, Ireland and Dr Gerard Clarke, University College Cork, Ireland

Stress-related disorders such as depression are leading causes of disability worldwide but their pathophysiology remains poorly understood. Exercise interventions are often deployed to improve treatment outcomes associated with more conventional clinical treatment options. The aim of this symposium is to improve our understanding of the mechanisms underpinning the mental health benefits of exercise. Topics discussed will include a focus on biomarkers related to neurotransmission, neurogenesis, growth factors, and blood flow, and how they integrate with recent clinical and preclinical research charting the impact of exercise on the gut microbiota as a potential mediator of the benefits for mood and cognition.

Mental health and the kynurenine pathway: Does exercise influence the activity of the kynurenine pathway?: Professor Sophie Erhardt, Karolinska Institutet, Sweden
Physical activity for mental health: An update of the evidence: Dr Joseph Firth, University of Manchester, UK
Exercise and the microbiome-gut-brain axis: Moving beyond tryptophan metabolism: Ms Cassandra Elise Gheorghe, University College Cork, Ireland
Physical activity, exercise, myokines and muscle-brain crosstalk: Professor Bente Klarlund Pedersen, Rigshospitalet and University of Copenhagen, Denmark

Mechanisms of COVID-19: Interactions and Effects of SARS-CoV-2 on the Respiratory and Intestinal Epithelium

Organised by Dr Claire Smith, University College London, UK and Dr Stephen Keely, Royal College of Surgeons in Ireland, Ireland

For publication in The Journal of Physiology.

Whilst Covid-19 has prevented many of us from interacting with each other over the past 2 years, this symposium aims to bring us together virtually to discuss recent research into the interactions and effects of SARS-CoV-2 on epithelial tissues. Lung epithelia are well recognised targets for SARS-CoV-2 infection, causing an influenza-like disease, however recent data establishes the intestinal epithelium as another important target for SARS-CoV-2. Our speakers will report on their work using various model systems aiming to elucidate common mechanisms of viral interactions with the respiratory and intestinal epithelium.

Manipulation of cellular pathways by SARS-CoV-2 in the gastro-intestinal tract: Dr Megan Stanifer, University of Heidelberg, Germany
Human organoid systems to study the pathogenesis, cell biology and evolution of SARS-CoV-2: Mart Lamers, Erasmus University Rotterdam, The Netherlands
Effects of SARS-CoV-2 infection on airway epithelial ion transport: Professor Martina Gentzsch, University of North Carolina, USA
Assessment of SARS-CoV-2 transmission potential under experiment settings and in an acute healthcare setting: Dr Jay, Jie Zhou, Imperial College London, UK

Ten Years On: Nanojunctions Coordinate Cellular Signalling by Directing Site-Specific Calcium Flux

Organised by Professor A. Mark Evans, University of Edinburgh, UK

For publication in The Journal of Physiology.

It is generally accepted that calcium stores are distributed throughout the Sarco / Endoplasmic Reticulum (S/ER) from its origins at the outer nuclear membrane to the plasma membrane, and that the S/ER delivers calcium signals with clear diversities of form and function.

Excitingly, a mechanism by which calcium signals may provide additional layers of regulation has been revealed through the discovery by the recent discovery of the “cell‑wide web”, a network of cytoplasmic nanocourses spanning from nuclear envelope invaginations to the plasma membrane, where all nanocourses are demarcated by S/ER nanojunctions (£400nm across) and strategically positioned, nanocourse‑specific calcium pumps and release channels.

This symposium will explore the power of site-specific in smooth muscle and astroglia.

Casey van Breemen and the Pan-junctional SR hypothesis: an historical perspective: Professor A. Mark Evans, University of Edinburgh, UK
Coordinated functions of STIM-Orai complexes fine tune calcium flux across nanojunctions of the ER/SR, plasma membrane and mitochondria: Professor Mohamed Trebak, Pennsylvania State University College of Medicine, USA
ER-dependent scaling of site-specific calcium transients in astroglia: Dr Kirsten Bohmbach, University of Bonn, Germany
Calcium signalling across the cell-wide web and its nuclear envelope invaginations: Coordinating cellular process and gene expression by directing site-specific calcium flux: Professor A. Mark Evans, University of Edinburgh, UK
How may site-specific calcium flux regulate gene expression rat nuclear envelope invaginations?: Professor Eric C. Schirmer, University of Edinburgh, UK

PC067 Phenotyping of human induced pluripotent stem cell-derived atrial cardiomyocytes and determination of responsiveness to a small conductance, calcium-activated potassium channel inhibitor

Andrew Butler¹, Stephen Harmer¹, Neil Marrion¹, Jules C Hancox¹¹University of Bristol, United Kingdom

PC068 Signaling pathways activated by G protein-coupled receptors in essential hypertension: differential contribution of Gq11 and G12-13 proteins

Nuria Daghbouche-Rubio¹, Pilar Cidad¹, Esperanza Alonso¹, Virginia Revuelto Fernández¹, M Teresa Pérez-García ¹, José R. López-López ¹¹Universidad de Valladolid y CSIC, Spain

PC070 Ventricular myocyte action potential responses to adrenergic stimulation and changes in rate

Luke Howlett¹, Hannah Kirton¹, Zhaokang Yang¹, Moza Al-Owais¹, Derek Steele¹, Matthew Lancaster¹¹University of Leeds, United Kingdom

PC071 Microcirculation in a murine model of pregnancy: novel technique for endoscopic blood flow visualisation and optimised endothelial assessment

Lukas Markwalder¹, Claire Sneddon¹, Rodney Gush², Nikola Krstajic¹, Colin Murdoch¹¹University of Dundee, United Kingdom ²Moor Instruments, Axminster, United Kingdom

PC072 Ion channel expression in the equine heart - In-silico prediction utilising RNA sequencing data from mixed tissue samples

Antoine Premont¹, Charlotte Edling¹, Rebecca Lewis¹, Kamalan Jeevaratnam¹¹University of Surrey, Guildford, United Kingdom

PC073 hENT1-mediated adenosine uptake is reduced by intracellular alkalization in human umbilical vein endothelial cells from gestational diabetes mellitus

Gonzalo Fuentes^{1, 2, 3}, Paola Valero^{1, 2}, Marcelo Cornejo^{1, 2, 4}, Harry van Goor³, Luis Sobrevia^{1, 3, 5, 6, 7}¹Pontificia Universidad Católica de Chile, Santiago, Chile ²Universidad de Talca, Chile ³University Medical Center Groningen (UMCG), University of Groningen, The Netherlands ⁴Universidad de Antofagasta, Chile ⁵Sao Paulo State University, Brazil ⁶Universidad de Sevilla, Spain ⁷University of Queensland Centre for Clinical Research, Brisbane, Australia

PC074 Does the small conductance Ca2+-activated K+ current (ISK) flow during atrial action potential repolarisation under physiological conditions?

Alessandro Giommi¹, Godfrey Smith¹, Antony Workman¹¹University of Glasgow, United Kingdom

PC075 Functional exercise increases perfusion disparity in healthy human lower limb in both sexes

Sérgio Nuno^{1, 2, 3}, João Gregório¹, Margarida Florindo^{1, 4}, Luís Monteiro Rodrigues¹¹Universidade Lusófona CBiOS (Research Center for Biosciences and Health Technologies) Campo Grande 376, 1749-024, Lisboa, Portugal ²ESTeSL-IPL Escola Superior de Tecnologia da Saúde de Lisboa – Instituto Politécnico de Lisboa, Lisbon Polytechnic Institute – Lisboa, Portugal ³Clínica São João de Deus – CTD, Lisboa, Portugal ⁴ESSCVP Escola Superior de Saúde da Cruz Vermelha Portuguesa – Lisboa: Departamento de Fisioterapia. Av. De Ceuta, Lisboa, Portugal

PC076 Long-term local vibrations affect skin oxygenation and motor nerve conduction in the arm of workers reporting wrist discomfort during computer mouse work

Ivana Potočnik¹, Nejka Potočnik²¹University of Maribor, Slovenia ²University of Ljubljana, Slovenia

PC077 Exploring the effect of a single meditation session on cutaneous microcirculation – a pilot study

Henrique Silva^{1, 2}, Beatriz Donato³, Hugo Ferreira³¹Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Portugal ² Faculdade de Farmácia, Universidade de Lisboa, Portugal ³Institute of Biophysics and Biomedical Engineering, Universidade de Lisboa, Portugal

PC078 Maternal high-fat high-sugar diet induces metabolic alterations related to hepatic and pancreatic changes that are independent of changes in body composition

Alejandro A. Candia^{1, 2}, Samantha C. Lean¹, Edina Gulacsi¹, Amanda Sferruzzi-Perri¹¹Centre for Trophoblast Research, University of Cambridge, United Kingdom ²Department for the Woman and Newborn Health Promotion, Universidad de Chile, Santiago, Chile

PC079 Characterization of CaV1.2 calcium voltage-gated channels of rat visceral white fat adipocytes using recombinant expression cloning

Olena Fedorenko¹, Paul A. Smith¹¹University of Nottingham, United Kingdom

PC080 The effects of adropin on adipokine expression in rodent adipocytes

Mariami Jasaszwili¹, Marek Skrzypski¹¹Poznań University of Life Sciences, Poland

PC081 Cyclotide fraction of cajanus cajan improves insulin signaling in a model of Type 2 Diabetic rats

Williams Nabofa¹, Chinaza Anosike¹, Francis Attah², AbdulRasak Alada³¹Babcock University, Ilishan-Remo, Nigeria ²University of Ilorin, Nigeria ³University of Ibadan, Nigeria

PC082 The colonic catabolism of black rice anthocyanins by the gut microbiota

Emad Shehata^{1, 2}, Priscilla Day-Walsh¹, Lee Kellingray¹, Mark Philo¹, Shikha Saha¹, Arjan Narbad¹, Paul Kroon¹¹Quadram Institute Bioscience, Norwich, United Kingdom ²National Research Centre, Cairo, Egypt

PC083 Neurophysiological implications of CPT1C deficiency: from synapse to behaviour

Guillermo Iborra-Lázaro¹, Irene Sánchez-Rodríguez¹, Souhail Djebari¹, Nuria Sánchez-Fernández², Marija Radosevic³, Esther Gratacòs-Battle^{2, 3}, Juan D. Navarro-López¹, David Soto^{2, 3}, Lydia Jiménez-Díaz¹¹Neurophysiology & Behavioral Lab, CRIB, School of Medicine of Ciudad Real, University of Castilla-La Mancha, Ciudad Real, Spain ²Laboratory of Neurophysiology, Department of Biomedicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain ³August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain

PC084 Fasting-induced torpor in mice: implications for behavioural neuroscience research

Sian Wilcox¹, Carina Pothecary ², Laura McKillop¹, Vincent Van der Vinne^{1, 3}, Stuart Perison², David Bannerman⁴, Vladyslav Vyazovskiy¹¹Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom ²Nuffield Department of Clinical Neurosciences, Sleep and Circadian Neurosciences Institute, University of Oxford, United Kingdom ³Department of Biology, Williams College, Williamstown, MA, The United States of America ⁴Department of Experimental Psychology, University of Oxford, United Kingdom

Cardiac & Vascular Physiology D

14:00 OC58 Vectorcardiographic, attractor-based analysis for adaptive real-time arrhythmia detection: Renuka Chintapalli, University of Cambridge, United Kingdom
14:15 OC59 The middle cerebral artery blood velocity response to moderate and heavy intensity cycling in healthy adults: Max Weston, University of Exeter, United Kingdom
14:30 OC60 Molecular basis for targeting CamKII in Nav1.5- and Ca2+-mediated arrhythmic syndromes: Khalil Saadeh, University of Surrey, United Kingdom and University of Cambridge, United Kingdom
14:45 OC61 Effects of cardiac geometric remodeling during heart failure on cardiac function: Yu Zheng, National University of Singapore, Singapore
15:00 OC62 Regulation of blood–brain barrier integrity by microbiome-associated dietary methylamines: Simon McArthur, Queen Mary, University of London, United Kingdom
15:15 OC63 Associations between physical activity and sedentary time with endothelial function, arterial elasticity, arterial stiffness and clustered cardiometabolic risk in children: The ALSPAC study: Kate Sansum, University of Exeter, United Kingdom

Human, Environmental & Exercise Physiology B

14:00 OC64 Nordic hamstring exercise metrics: how valid are they?: Emma Sconce, Sheffield Hallam University, United Kingdom
14:15 OC65 Heart rate variability diverse metrics as summary indexes of physiological interconnectedness and adaptability: examples of response to high-altitude trekking and during listening to Mozart music: Danilo Bondi, University "G' d'Annunzio" of Chieti - Pescara, Chieti, Italy
14:30 OC66 Pulmonary ventilation and gas exchange during prolonged exercise with distinct hydration and circulation levels: influence of dehydration, hyperthermia and sympatho-adrenergic activity: Professor José González-Alonso, Brunel University London, United Kingdom
14:45 OC67 Cardiovagal modulation is acutely reduced following high-intensity interval exercise but not moderate-intensity continuous exercise in physically active young and older male adults: João Luís Marôco, University of Lisbon, Portugal
15:00 OC68 Regulation of phase reset mechanism in mammalian circadian rhythms by oligonucleotide therapeutics: Kazuo Nakazawa, Toyohashi University of Technology, Japan

Short palate and nasal epithelial clone 1 (SPLUNC1) is an allosteric regulator of cation channels

Professor Robert Tarran, University of North Carolina at Chapel Hill, USA

A colourful experience

Professor Semir Zeki, University College London, UK

Molecular Basis of Proteinuric Disease

Organised by Professor Ora Weisz, University of Pittsburgh, USA
In association with the American Physiological Society

Urinary excretion of protein (proteinuria) is a common sign of kidney injury and poses a substantial risk for progressive debilitating disease. In many instances, glomerular damage is preceded by tubular proteinuria, resulting from impaired function of the kidney proximal tubule due to environmental or pharmacologic damage, diabetes, or genetic mutations. This symposium is focused on recent progress in deciphering the molecular mechanisms that impair tubular and glomerular function to cause proteinuric disease.

Sponsored by the American Physiological Society

Molecular drivers of progressive renal injury in sickle cell disease: Professor Jennifer Pollock, University of Alabama Birmingham, USA
Clinical progression of proteinuric disease: Professor Nigel Brunskill, University of Leicester, UK
A model of megalin trafficking in the proximal tubule: Katherine Shipman, University of Pittsburgh, USA
Megalin and cubilin function in proteinuric disease: Dr Kathrin Weyer, Aarhus University, Denmark

New Drugs for Old Transporters: What Have We Missed?

Organised by Professor Carsten Ehrhardt, Trinity College Dublin, Ireland and Dr Jessica Ann Dominguez Rieg, University of South Florida, USA

This session will provide an overview of transporters and their impact on physiology and pharmacotherapy with a focus on recent advances in our understanding of the (patho)physiology of membrane transporters. There will be an emphasis on transporters as molecular targets. Transporter mutations are responsible for more than 100 Mendelian diseases. Transporters, therefore, represent a host of new therapeutic targets for treating rare diseases as well as more common diseases, as recently shown for sodium-glucose cotransport inhibitors. However, there are several other examples that need to be considered. This session will summarize some of these recent developments.

Novel insights into the role of intestinal NHE3 as a therapeutic target: Dr Jessica Dominguez Rieg, University of South Florida, USA
Transporters feat. the lung: What do we learn from current understandings: Dr Johanna Salomon, University of Heidelberg, Germany
Npt2a as a target for treating hyperphosphatemia with and without kidney disease: Dr Timo Rieg, University of South Florida, USA
Pathophysiological significance of the prostaglandin transporter SLCO2A1 in lung inflammation: Professor Takeo Nakanishi, Takasaki University of Health and Welfare, Japan

Photoreceptors in Health and Monogenic Disease: Advances in Understanding Physiology and Treating Pathophysiology

Organised by Dr Omar Mahroo, University College London, UK and Dr Emma Duignan, Trinity College Dublin, Ireland

For publication in The Journal of Physiology.

Photoreceptors are highly specialised cells, the first neurons in vision. Inherited photoreceptor degenerations are key causes of blindness certification in working age adults in many countries. This symposium will present an overview together with recent developments in pertinent areas, including phototransduction, in vivo human retinal electrophysiology, mechanisms of disease, and new therapeutic approaches. The topics are timely given recent milestones in understanding photoreceptor physiology and pathophysiology, accessibility of whole genome sequencing and novel therapies. The symposium is relevant to scientists and clinicians, particularly those working within visual neuroscience or genetics.

Probing photoreceptor physiology and pathophysiology in vivo using electrophysiology: Miss Xiaofan Jiang, University College London, UK
Photoreceptor physiology: Cellular and molecular basis of rod and cone phototransduction: Professor Trevor D Lamb, Australian National University, Australia
Monogenic retinal disease: Mechanisms and the landscape of novel therapies: Professor Anthony T Moore, University of California San Francisco, USA
Restoring vision after photoreceptor degeneration using optogenetic techniques: Dr Samantha De Silva, University of Oxford, UK

Physiological Resilience Across the Lifecourse: In Utero and Beyond

Organised by Professor Michael Taggart, Newcastle University, UK and Professor Rachel Tribe, King’s College London, UK

For publication in Experimental Physiology.

There is increasing awareness that understanding the physiological responses to many challenges faced throughout the lifecourse, from in utero and beyond, is necessary to inform us of health trajectories and improve the long-term well-being of individuals and populations. In this symposium, therefore, we will examine the role of several organ systems – the placenta, kidney, heart and gut – in mediating the physiological resilience required for organism development and maturation over the lifecourse. In addition, we will consider situations when such responses are insufficient, or overwhelmed, and the impact of these for disease onset.

Placental endocrine insufficiency programs atypical behaviour in mothers and their offspring: Professor Rosalind John, Cardiff University, UK
Acute and chronic cardiac adaptations in adults born preterm: Dr Adam Lewandowski, University of Oxford, UK
Impact of early life development and later onset chronic kidney disease and hypertension: Dr Valerie Luyckx, University of Zurich, UK
Development of the gut microbiome in early life: Dr Christopher Stewart, Newcastle University, UK

PC085 Atrial granules as acidic calcium stores in atrial cardiomyocyte physiology and disease

Rebecca A Capel¹, Emily Akerman¹, Thamali Ayagama¹, Eva Rog-Zielinska², Rebecca A.B. Burton¹¹University of Oxford, United Kingdom ²Institute for Experimental Cardiovascular Medicine, University Heart Center Freiburg · Bad Krozingen, and Medical Faculty of the University of Freiburg, Freiburg, Germany

PC086 Matrix metalloproteinase-9 expression levels in acute ischaemic stroke (AIS) clots of different etiologies

Andy Douglas^{1, 2}, Madalina Mereuta^{1, 2}, Rosanna Rossi^{1, 2}, Duaa Jabrah¹, Sean Fitzgerald¹, Abhay Pandit², Michael Gilvarry³, Ray McCarthy³, Klearchos Psychogios⁴, Istvan Szikora⁵, Jack Alderson⁶, Paul Brennan⁶, Sarah Power⁶, John Thornton⁶, Katarina Jood⁷, Alexandros Rentzos⁸, Turgut Tatlisumak⁷, Karen Doyle^{1, 2}¹Department of Physiology, School of Medicine, National University of Ireland, Galway, Ireland ²CÚRAM–Centre for Research in Medical Devices, National University of Ireland Galway, Ireland ³Cerenovus, Galway, Ireland ⁴Metropolitan Hospital, Department of Neuroradiology, Piraeus, Greece ⁵National Institute of Clinical Neurosciences, Budapest, Hungary ⁶Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland ⁷Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden ⁸Department of Interventional and Diagnostic Neuroradiology, Sahlgrenska University Hospital, Gothenburg, Sweden

PC087 Rescue of homeostatic regulation: the effect of drug vs lifestyle approach

Vera Geraldes^{1, 2}, Filipa Machado², Ângela Amaro-Leal^{1, 2}, Ana I. Afonso², Isabel Rocha^{1, 2}¹Faculdade de Medicina da Universidade de Lisboa, Portugal ²Centro Cardiovascular da Universidade de Lisboa, Portugal

PC088 Voltage-dependence of Na+ current inhibition by eleclazine in adult rat atrial and ventricular myocytes

Alexander Carpenter¹, Rachel E. Caves¹, Hongwei Cheng¹, Stephanie Choisy¹, Cameron McNiff², Ben Clennell¹, Jules C Hancox¹, Andrew James¹¹University of Bristol, United Kingdom ² University of Manchester, United Kingdom

PC089 Phase contrast X-ray CT for imaging of the entire circumferential structure of arteries under pulsatile pressure condition

Takeshi Matsumoto¹, Hiroyuki Tachibana², Masato Hoshino³¹Tokushima University, Japan ²Kawasaki University of Medical Welfare, Japan ³SPring-8, Sayo, Japan

PC090 Factors contributing to the discrepancies in 2D and 3D fetal echocardiography strain measurements

Meifeng Ren¹, Wei Xuan Chan¹, Aimee Armstrong ², Andreas Tulzer³, Gerald Tulzer³, Martin Lindsay Buist¹, Choon Hwai Yap⁴¹National University of Singapore, Singapore ²The Heart Center, Nationwide Children’s Hospital, Columbus, Ohio, The United States of America ³Kepler University Hospital, Linz, Austria ⁴Imperial College London, United Kingdom

PC091 Defective X-gating in the TASK-1 K+ channel caused by de novo mutations in KCNK3 produces a developmental disorder with sleep apnea

Janina Sörmann¹, Marcus Schewe², Peter Proks¹, Shanlin Rao³, Thibault Jouen-Tachoire¹, Thomas Müller⁴, Thomas Baukrowitz², Matthew E. Hurles⁵, Caroline F. Wright⁶, Stephen J. Tucker¹¹Department of Physics, University of Oxford, United Kingdom ²Institute of Physiology, Christian-Albrechts University of Kiel, Germany ³Department of Biochemistry, University of Oxford, United Kingdom ⁴Bayer AG, Research & Development, Pharmaceuticals, Wuppertal, Germany ⁵Human Wellcome Sanger Genetics Programme, Institute, Wellcome Genome Campus, Hinxton, United Kingdom ⁶Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon & Exeter Hospital, United Kingdom

PC092 Ferulic acid enhanced L-type Ca2+ channel function and insulin secretion in rat insulinoma cell line

Katesirin Ruamyod¹, Wattana Watanapa¹, Pimchanok Nambandit¹, Chanrit Kakhai¹, Sukrit Treewaree¹, Parin Wongsanupa¹¹Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

PC093 Increased expression of (pro)renin receptor by anti-cancer drugs in cultured cancer cells: Relation to apoptosis and autophagy

Yurina Kashio-Yokota¹, Shigemitsu Sato¹, Takuo Hirose¹, Tomoki Watanabe¹, Akari Endo¹, Fumihiko Watanabe¹, Moe Endo¹, Koji Ohba¹, Takefumi Mori², Kazuhiro Takahashi¹¹Tohoku University Graduate School of Medicine, Sendai, Japan ²Tohoku Medical and Pharmaceutical University, Sendai, Japan

PC094 Animation for the hypothesis that the cervix transforms into the lower uterine segment through the TYVU and an inverted U pattern due to direct and indirect uterine cervical interaction and its subsequent reversal

Ali Hegazy¹¹Portiuncula University Hospital, Ballinasloe, Ireland

PC095 Animation for the hypothesis that the cervix dictates the pregnancy interval and circadian timers through exponential uterine wall tension with light-dark cycle modulation

Ali Hegazy¹¹Portiuncula University Hospital, Ballinasloe, Ireland

PC096 Effects of acute and chronic high intensity muscle contractions on irisin and related factor expression in mice skeletal muscle

Riku Tanimura¹, Kazuki Uemichi¹, Katsuyuki Tokinoya^{2, 3}, Takanaga Shirai³, Tohru Takemasa¹¹University of Tsukuba, Japan ²Tokyo Metropolitan University, Japan ³Japan Society for the Promotion of Science, Tokyo, Japan

PC097 Effects of mechanistic/mammalian target of rapamycin complex 1 inhibition on mitochondrial dynamics-related signaling induced by acute or chronic resistance exercise in mouse skeletal muscle

Kazuki Uemichi¹, Riku tanimura¹, Takanaga Shirai², Tohru Takemasa¹¹Tsukuba University, Japan ²Japan Society for the Promotion of Science, Tokyo, Japan

PC098 Maternal and fetal p110α deficiency induces sex-specific changes in feto-placental growth and placental mitochondrial function

Daniela Carvalho¹, Jorge Lopez-Tello¹, Esteban Salazar¹, Amanda Sferruzzi-Perri¹¹Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, United Kingdom

PC099 In vivo body composition analysis - comparing data from Dual Energy X-ray Absorptiometry (DXA) and Bioelectrical Impedance Analysis (BIA)

Cíntia Ferreira-Pêgo¹, Rejane Giacomelli Tavares¹, Sofia Lopes², Tatiana Fontes², Luís Monteiro Rodrigues¹¹CBIOS – Universidade Lusófona’s Research Center for Biosciences & Health Technologies, Lisbon, Portugal ²School of Sciences and Health Technologies Universidade Lusófona de Humanidades e Tecnologias, Lisbon, Portugal

PC100 The role of hypoxia in mouse pancreatic carcinogenesis - Effect of limited oxygen availability on the effectiveness of anti-cancer therapy

Daria Krzysztofik¹, Agnieszka Kusiak², Kinga Stopa¹, Paweł Ferdek², Ewa Werner¹, Karolina Hajduk¹, Jan Morys^{1, 2}, Sylwester Mosiołek^{1, 2}, Filip Łoziński^{1, 2}, Monika Jakubowska¹¹Małopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland ²Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland

PC101 Pleurotus tuber-regium inclusion in diet ameliorates dyslipidemia in obese-Type 2 diabetic rats

Adeyi Oluwatosin¹, Folasade Ajoke Adams², Clementina Oyinkansola Adenipekun²¹Department of Zoology, University of Ibadan, Nigeria ²Department of Botany, University of Ibadan, Nigeria

PC102 Nrf2 as a modulator of (patho)physiological calcium responses in murine pancreatic secretory cells - ex vivo studies

Kinga Stopa¹, Monika Paciorek¹, Agnieszka Kusiak², Paweł Ferdek², Monika Jakubowska¹¹Małopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland ²Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University , Kraków, Poland

PC103 Lateral symmetry in the force contractile properties of gastrocnemius muscles of rats

Joan Ramon Torrella¹, Garoa Santocildes¹, Marc Merino¹, Federica Fabiani¹, Teresa Pagès¹, Mario Marotta^{2, 3}, Ginés Viscor¹¹Department of Cellular Biology, Physiology and Immunology, University of Barcelona, Spain ²Bioengineering, Cell Therapy and Surgery in Congenital Malformations Laboratory, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Spain ³Leitat Foundation, Leitat Technological Center, Barcelona, Spain

PC104 Prion protein protects the large-conductance calcium-activated potassium channel from the inhibitory effect of Tau oligomers

Yevheniia Kravenska¹, Hanna Nieznanska², Krzysztof Nieznanski²¹University of Padova,, Italy ²Nencki Institute of Experimental Biology, Warsaw, Poland

PC105 Occurrence of mild cognitive impairment with hyperinsulinaemia in Africans with advanced Type 2 diabetes

Isyaku Yarube¹, Jamila Bashir²¹Bayero University , Kano, Nigeria ²Aminu Kano Teaching Hospital, Kano, Nigeria

Epithelia & Membrane Transport B

14:00 OC69 Application of molecular dynamics to elucidation of the mechanism of glucose transport via GLUT1: Saul Gonzalez-Resines, University of Bath, United Kingdom
14:15 OC70 Pharmacological inhibitors of the cystic fibrosis transmembrane conductance regulator exert off-target effects on store-operated calcium entry and epithelial sodium channel function: JinHeng Lin, Newcastle University, United Kingdom
14:30 OC71 Droplet electro-transfection by electrostatic field without contact charge electrophoresis : Ryuto Shinozaki, Toyohashi University of Technology, Japan
14:45 OC72 Nutraceutical targeting of the bile acid receptor, farnesoid X receptor, for intestinal disease: Ciara M Fallon, The Royal College of Surgeons, Dublin, Ireland
15:00 OC73 Protective effect of Phoenixin-14 on acetic acid-induced oxidative gastric injury in rats: role of the mucus layer and mast cells: Leyla Semiha Şen, Marmara University, Istanbul, Turkey
15:15 OC74 Characteristics of the inhibitory action of the novel small-molecule blocker of TRPC1/4/5 channels Pico145 on the muscarinic cation current in murine intestinal myocytes: Alexander Zholos, Taras Shevchenko National University of Kyiv, Ukraine

Metabolic Physiology B

14:00 OC75 Small molecule inhibition of CARM1 activity in skeletal muscle: Erin K Webb, McMaster University, Hamilton, Canada
14:15 OC76 The NAD+ dependent Poly ADP-ribose polymerase PARP-1 governs differentiation and energy metabolism of mouse skeletal muscle: Arnold Tan, Nottingham Trent University, United Kingdom
14:30 OC77 Chronic caffeine intake ameliorates adipose tissue function by improving angiogenesis, weight gain and metabolism: Solange M Farreca, CEDOC, NOVA Medical School, NOVA University Lisbon, Lisboa, Portugal
14:45 OC78 Thapsigargin blocks electromagnetic fields-elicited intracellular Ca2+ increase in stress-response in vitro model: Federico Bertagna, University of Surrey, UK
15:00 OC79 The zinc finger homeobox 3 transcription factor at the interface of regulating circadian rhythms and feeding behaviour: Nicole Morrissey, Medical Research Council, UK

Neuroscience C

14:00 OC80 Neuroprotective effect of plasminogen activator inhibitor-1 antagonist in the rat model of mild traumatic brain injury: Dr Pinar K Bektaşoğlu, Marmara University, Istanbul, Turkey and University of Health Sciences, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey
14:15 OC81 Brain activity of men and women during simple visual choice reaction task: Veronika Vozniuk, Taras Shevchenko National University of Kyiv, Ukraine
14:30 OC82 A G-protein dependent mechanism through adenosine A1 receptor-activated GirK channels is needed for synaptic plasticity processes in dorsal hippocampus: Souhail Djebari, University of Castilla-La Mancha, Ciudad Real, Spain
14:45 OC83 Multistable systems: a new general theory in pathophysiology with examples from nervous system disorders: Bruno Burlando, University of Genova, Italy

Reflecting on Research, Teaching and Life During the COVID-19 Pandemic

This townhall-style discussion will explore what life could look like for a researcher long-term following the COVID-19 pandemic. The panel will explore topics including positives to come from the pandemic and hopes for the future. There will be time for audience Q&A.

Chairs:

Professor Jonathan Ashmore, University College London, UK
Dr Ruth Norman, University of Leeds, UK

Speakers:

Olivia Pratt, King’s College London, UK
Greg Sutton, The University of Edinburgh, UK
Dr Charlotte Stagg, University of Oxford, UK

Registration

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ECR Non-member^*	£75.00	£125.00

^*please email events@physoc.org for the appropriate discount code.

Registration grants you access to the conference platform to watch presentations, take part in question and answer sessions, roundtable discussions, useful networking, and much more. All presentations will be available to watch on demand for up to 30 days from 17 July 2021 (this is subject to change).

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Abstract submission closed on 30 April and all submitting authors have been notified of a decision.

Guidelines for oral communications

Oral communications are strictly limited to 10 minutes duration (and five for discussion). This will be enforced by session chairs. Please ensure that your oral communication begins with an introduction that enables your audience to appreciate its context and the rationale for the study, and ends with a form of conclusion/summary that emphasises the key points. Remain focused upon the experimental procedures and data, and avoid over speculation. Clarity in your presentation, both audio and visual, will ensure the audience is sufficiently informed to be able to appreciate your work and also to be in a position to ask pertinent questions.

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Not more than six slides should be shown, NOT including title slide and acknowledgements.
Any PowerPoint animations should be ‘basic’
Graphs should not normally contain more than three curves
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All presenters are required to join the session 30 mins before the scheduled start time to enable the Technical Chair to run through the set up with you. Questions will be submitted via a chat function and the session chair will read the questions to you, and then you can answer.

ePoster presentations

The ePosters for Physiology 2021 will be created using the platform Kubify – Learning Toolbox for ePosters. Find out what an ePoster is here.

The support page for Physiology 2021 can be found here.

You can also view the ePoster showcase for Future Physiology 2021 here.

Competitions

There will be both oral communication competitions and ePoster competitions for Early Career Researchers as part of Physiology 2021. More information will be available shortly.

Key Info

Registration opens	25 February 2021
Abstract submission opens	1 April 2021
Abstract submission closes	30 April 2021
Abstract decisions issued	23 May 2021
Decisions on oral or ePoster issued	26 May 2021
Early bird registration deadline	31 May 2021
Final schedule available	31 May 2021
Kubify ePoster webinar	3 June 2021 at 15:00 BST
Registration deadline	30 June 2021
Platform log in details sent	7 July
Meeting dates	12 – 16 July 2021

Exhibitors & Sponsors

The Society’s annual conference brings together members of The Society and the wider physiology community all actively working in academia, research and teaching, or industry.

Opportunities to take part in Physiology 2021 will be available shortly.

For all informal enquiries, please email events@physoc.org

Changes in cellular Ca2+ and Na+ regulation during the progression towards heart failure

This symposium talk aims to give an overview of the role played by the cardiac sodium channel in the decline in function of the heart as it begins to fail. The following summary will provide some background for the talk. In adapting to disease and loss of tissue the heart shows great phenotypic plasticity that involves changes to its structure, composition and electrophysiology. In parallel, global cardiovascular adaptations occur involving stimulation of the sympathetic nervous system, release of natriuretic peptides and activation of the renin-angiotensin-aldosterone pathway. These adaptations provide compensation for the initial decline in cardiac function but, for reasons not understood, do not provide continued benefit in the longer term. The heart begins to fail in its task to produce sufficient cardiac output to meet the body’s requirements for oxygen and nutrients. Heart failure is a chronic and progressive condition with very poor prognosis. Approximately 60% of people diagnosed with heart failure are dead within five years and, although exact percentages depend on the type of failure, up to half of those will die from disturbances of rhythm. At the cellular level compensation responses involve a spectrum of changes to structure, electrophysiology and Ca2+ homeostasis. There is an increase in late Na+ current and a decrease in Na+/K+ ATPase current. The cardiac myocytes gain Na+ and this alters the balance of Ca2+ flux mediated by the Na+/Ca2+ exchange that limits early contractile impairment. Action potential duration prolongs as a result of the increase in late Na+ current and changes in the expression and function of other ion channels and transporters, notably those carrying K+. Cytosolic Na+ perturbations can disturb Ca2+-dependent energy metabolism and reactive oxygen production in mitochondria reducing energy supply. The normal spatial arrangements of Ca2+-handling proteins are essential for efficient excitation–contraction (EC) coupling and the stability of this amplification mechanism. There is a reduction in T-tubule density in myocytes from failing hearts leading to an increased spatial separation of the junctional SR from the T-tubule membrane. These structural changes are thought to underlie temporal delays in EC coupling and an increase in spontaneous Ca2+-release events (Ca2+ sparks). It is likely that these structural and electrophysiological responses occur at the expense of (1) increasing the likelihood of arrhythmogenesis, (2) activating hypertrophic and apoptotic signalling pathways and (3) decreasing the efficiency of EC coupling. The combination of action potential prolongation, altered Na+ regulation, inconsistent Ca2+ release from SR and a less stable ventricular membrane potential provides a setting for triggered arrhythmias initiated either by early or delayed afterdepolarizations. The cardiac sodium channel plays an important role in the passage of the heart from function to dysfunction.

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Physiology in Focus 2024

Monday 12 July - Friday 16 July 2021

Physiology 2021

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Teaching physiology: Past, present, and future

Cardiac Sodium Channel: From Function to Dysfunction

Conceptual Learning in Physiology

Metabolic and Endocrine Influences of the Menstrual Cycle and Hormonal Contraceptives: Methodological Considerations for Research in Eumenorrheic Females

TMEM16: New Insights into Transmembrane Proteins of Broad Physiological Relevance in Health and Disease

PC001 Angiotensin receptor clustering and hypoxic remodelling in O2 sensitive cells

PC002 Cycle length dependence of electrical and mechanical alternans in guinea pig ventricular myocytes

PC003 Acute modification of upper-limb perfusion in vivo evokes a Prompt Adaptive Hemodynamic Response to re-establish cardiovascular homeostasis

PC004 Pathological turret mutations in the cardiac sodium channel Nav1.5 induce long-range disruption to the pore geometry

PC005 Autonomic nervous system response to facial cooling increases velocity of left ventricle contraction and aortic compliance measured by pulse wave analysis

PC006 Lysosomal calcium release modulates β-adrenergic response and arrhythmogenicity in ventricular cardiomyocytes by increasing SERCA activity

PC007 Transcriptional profiles of genes related to electrophysiological function in Scn5a+/- murine hearts

PC008 The role of cardiopulmonary exercise testing (CPET) in predicting mortality and morbidity in people with congenital heart disease: a systematic review and meta-analysis

PC009 Student evaluation: Changes to a physiology module in response to COVID-19

PC010 Perception about teaching and learning methodologies applied in physiology, a study on medical students of Pakistan

PC011 Physiology education in Nigeria: Faculty opinions on challenges and suggested solutions

PC012 Assessment of repeatability using structured light plethysmography technique compared to spirometry

PC013 Influence of posture on the foot perfusion in the upright position

PC014 Evaluating the efficacy of primary dysmenorrhoea management methods and their accessibility under universal health coverage

PC015 Microbial-metabolite pathways associated with cervicovaginal infection and spontaneous preterm birth: A systematic review

PC016 Glucagon-like peptide 1 (GLP-1) secretion from gut endocrine cells is pH dependent

PC017 Transcriptome and methylome of the term human placenta in gestational diabetes mellitus: A systematic review and meta-analysis

PC018 Carotid body modulation decreases weigh gain and reverts dysmetabolism by ameliorating adipose tissue function and restoring sympathetic integration

PC019 Identification of novel human gut microbiota metabolites from cyanidin- and delphinidin-type anthocyanins

PC020 Effect of BMI on the motor nerve conduction study among medical students of AL-Neelain University

PC021 Psychoneuroimmunology of meditation

Cardiac & Vascular Physiology A

Education & Teaching A

Metabolic Physiology A

Neuroscience A

Student Learning in the Fourth Industrial Revolution: Why Attend Class when it’s all Online?

Hidden clocks: Circadian rhythms and the vulnerable fetus

Seeing, Feeling, and Hearing Electrophysiology in Excitable Organs: Next-generation Electrophysiology

The Future of Targeting Glucagon-Like Peptide-1 Signalling in Obesity Treatment: New Insights from Physiology

The Many Facets of the Microcirculation in Health and Disease

PC022 Chronic intermittent hypoxia in utero depresses basal carotid body activity and hypoxic sensitivity in adult offspring

PC023 Cardiac troponin T amino terminus is required for inhibition of Ca2+- dependent sliding of thin filaments

PC024 Regular walking significantly improves foot perfusion independently of age

PC026 Does a reduction in Nav1.5 protein expression within the right atria increase an elderly patient’s susceptibility to atrial fibrillation?

PC027 Reliable identification of cardiac liability in drug discovery using automated patch clamp: Considerations and best practices for high throughput recordings of NaV1.5

PC028 Carbon nanotube-based scaffolds for cardiac tissue engineering – Systematic review and narrative synthesis

PC029 Noradrenaline stimulates human atrial L-type Ca2+ current by activating β1-adrenoceptors, and to a smaller degree α1, with a mixed and minor contribution from β2 and α2

PC030 Assessment of hair cortisol in euthyroid, hypothyroid, and subclinical hypothyroid subjects

PC031 Modulation of L-type voltage-gated calcium channels interferes with intracellular calcium mobilisation in mouse white fat adipocytes

PC032 Vitamin D receptor activation exerts anti-secretory actions in colonic epithelial cells

PC033 Vaginal chemokine delivery system for pelvic floor muscular dysfunction and urinary incontinence prophylaxis and therapy

PC034 Carotid body chemosensitivity at rest and during exercise in patients with hypertension

PC035 Observations on the interaction between perfusion and postural stability in both feet during movement

PC036 Continuous compared to accumulated multicomponent-training on physical function and health-related quality of life in sedentary elderly

PC037 The Effect of Gum Arabic Supplementation on Cathelicidin expression in Monocyte Derived Macrophages in Mice

PC038 Influence of season on the modulating role of ascorbic acid and L-carnitine on respiratory rate of African giant rats (cricetomys gambianus, waterhouse - 1840)

PC039 Physiology of body composition – how do vegetarians and omnivores differ?

PC040 Anti-inflammatory and anti-oxidative properties of aqueous extract of Triticum aestivum (common wheat) on acetic acid-induced colitis in Wistar rats

PC041 Evaluating the leucine trigger hypothesis to explain the postprandial regulation of muscle protein synthesis in young and older adults: A systematic review

PC042 Mapping the daily rhythmic transcriptome in the diabetic retina

PC043 In Silico Investigation on possible involvement of neuroendocrine modulations in diabetic peripheral neuropathy

Cardiac & Vascular Physiology B

Epithelia & Membrane Transport A

Human, Environmental & Exercise Physiology A

Regulation of blood flow at the capillary level in health and disease

The gut endocrine axis in the control of metabolism

Decoding Prefrontal Cortical Physiology: Circuits of Cognition

Dissecting Interactions Regulating the Thyroid by Functional Imaging and Manipulation

Microbiomes in Physiology

Skeletal Muscle from Molecules to Movement

PC044 Biochemical signalling pathways are disrupted in the myocardium of mdx 5cv mice and not rescued by ΔR4-R23/ΔCT micro-dystrophin

PC045 Palmitoylation and regulation of the “funny” current HCN4 channel

PC046 Action potential clamp characterization of a short QT syndrome “hotspot” hERG mutation

PC047 LQTS-Associated calmodulin mutations disrupt interactions with the Kv7.1 voltage-gated potassium channel